Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study

LB Saltz, S Clarke, E Díaz-Rubio… - Journal of clinical …, 2008 - ascopubs.org
Purpose To evaluate the efficacy and safety of bevacizumab when added to first-line
oxaliplatin-based chemotherapy (either capecitabine plus oxaliplatin [XELOX] or …

Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern …

BJ Giantonio, PJ Catalano, NJ Meropol… - Journal of clinical …, 2007 - ascopubs.org
Purpose Colorectal cancer is the second leading cause of cancer mortality in the United
States. Antiangiogenic therapy with bevacizumab combined with chemotherapy improves …

[HTML][HTML] Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study

E Van Cutsem, F Rivera, S Berry, A Kretzschmar… - Annals of …, 2009 - Elsevier
Background Bevacizumab significantly improves survival when added to chemotherapy for
metastatic colorectal cancer (mCRC). The Bevacizumab Expanded Access Trial (BEAT) …

Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE …

HS Hochster, LL Hart, RK Ramanathan… - Journal of Clinical …, 2008 - ascopubs.org
Purpose To evaluate the safety and efficacy of three oxaliplatin and fluoropyrimidine
regimens, with or without bevacizumab, as first-line treatment for metastatic colorectal …

[HTML][HTML] Efficacy of bevacizumab in first-line treatment of metastatic colorectal cancer: A systematic review and meta-analysis

A Baraniskin, B Buchberger, C Pox, U Graeven… - European Journal of …, 2019 - Elsevier
Background This systematic review and meta-analysis aims to evaluate the additive effect of
bevacizumab when combined with first-line chemotherapy in metastatic colorectal cancer …

[HTML][HTML] Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP …

G Masi, L Salvatore, L Boni, F Loupakis, C Cremolini… - Annals of …, 2015 - Elsevier
The BEBYP trial is a prospective, randomized, open-label, multicenter, phase III study
evaluating the continuation or reintroduction of bevacizumab with second-line …

Efficacy and safety of bevacizumab in metastatic colorectal cancer: pooled analysis from seven randomized controlled trials

HI Hurwitz, NC Tebbutt, F Kabbinavar… - The …, 2013 - academic.oup.com
Purpose. This analysis pooled individual patient data from randomized controlled trials
(RCTs) to more thoroughly examine clinical outcomes when adding bevacizumab to …

[HTML][HTML] Effectiveness of bevacizumab added to standard chemotherapy in metastatic colorectal cancer: final results for first-line treatment from the ITACa randomized …

A Passardi, O Nanni, D Tassinari, D Turci, L Cavanna… - Annals of …, 2015 - Elsevier
Background We report the results from a first-line phase III randomized clinical trial on
metastatic colorectal cancer (mCRC) aimed at evaluating the effectiveness of adding …

Safety and efficacy of bevacizumab (Bev) when added to oxaliplatin/fluoropyrimidine (O/F) regimens as first-line treatment of metastatic colorectal cancer (mCRC) …

HS Hochster, L Welles, L Hart… - Journal of Clinical …, 2005 - ascopubs.org
3515 Background: Bevacizumab (Bev) added to IFL combination chemotherapy improves
survival in mCRC. This randomized study assesses the safety & tolerability of each of three …

A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer

Y Cao, A Tan, F Gao, L Liu, C Liao, Z Mo - International journal of …, 2009 - Springer
Purpose Bevacizumab has demonstrated survival benefit in metastatic colorectal cancer
(mCRC) patients when combined with chemotherapy. Several randomized clinical studies …