We show that AP‐1 is an antioxidant‐responsive transcription factor. DNA binding and
transactivation by AP‐1 were induced in HeLa cells upon treatment with the antioxidants …

The transcription factors NF-kappa B and AP-1 have been implicated in the inducible
expression of a variety of genes involved in responses to oxidative stress and cellular …

Publisher Summary The eukaryotic transcription factor system specifically activated by
peroxides is NF-κB. Micromolar concentrations of H 2 O 2 can mobilize the sequestered …

NF-kappa B is a widely used regulator of inducible and tissue-specific gene control. In the
cytosol, when complexed to an inhibitory molecule, I kappa B, NF-kappa B is in an inactive …

Transcription factors AP-1 and NF-κB have been implicated in the inducible expression of a
variety of genes in response to oxidative stress. Recently, based on the observation that …

Reactive oxygen species are thought to be messengers for nuclear factor (NF)-kappa B
activation because its activation can be abrogated by antioxidants. However, this study …

Although it is generally believed that reactive oxygen species activate NF-κB, a primary
oxidative stress-responsive transcription factor, it is unclear which one among these species …

There is increasing evidence that reactive oxygen intermediates (ROIs) play an important
role in cellular processes such as signal transduction and the control of gene expression …

Studies presented here show that overall NF-kappa B signal transduction begins with a
parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor …

The ability to induce cellular defense mechanisms in response to environmental challenges
is a fundamental property of eukaryotic and prokaryotic cells. We have previously shown that …