Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …

The transcription factor RUNX3, which mediates apoptosis and cell growth inhibition in
gastric epithelial cells, is a candidate tumor suppressor that is frequently lost in gastric …

Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …

As the infectious agent causing human adult T-cell leukemia (ATL), the human T-cell
leukemia virus type 1 (HTLV-1) virus spreads in vivo primarily by cell-to-cell transmission …

Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and
apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis …

FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …

Background: Melatonin induces apoptosis in many different cancer cell lines, including
hepatocellular carcinoma cells. However, the responsible pathways have not been clearly …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …

Elevated expression or activity of the transcription factor forkhead box M1 (FOXM1) is
associated with the development and progression of many malignancies, including breast …