[PDF][PDF] DNA methylation signatures in development and aging of the human prefrontal cortex
S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain
regions to mature. To investigate the role of epigenetics in the development of PFC, we …
regions to mature. To investigate the role of epigenetics in the development of PFC, we …
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …
methylation has been suggested to be a central mechanism in development, some disease …
[PDF][PDF] DNA methylation signatures within the human brain
C Ladd-Acosta, J Pevsner, S Sabunciyan… - The American Journal of …, 2007 - cell.com
DNA methylation is a heritable modification of genomic DNA central to development,
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …
[HTML][HTML] DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
KD Siegmund, CM Connor, M Campan, TI Long… - PloS one, 2007 - journals.plos.org
The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and
function, during normal and pathological brain development and aging remains unclear …
function, during normal and pathological brain development and aging remains unclear …
[HTML][HTML] DNA methylation and adult neurogenesis
EM Jobe, X Zhao - Brain Plasticity, 2017 - content.iospress.com
The role of DNA methylation in brain development is an intense area of research because
the brain has particularly high levels of CpG and mutations in many of the proteins involved …
the brain has particularly high levels of CpG and mutations in many of the proteins involved …
Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
A Kozlenkov, P Roussos, A Timashpolsky… - Nucleic acids …, 2014 - academic.oup.com
Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …
[PDF][PDF] Genetic control of individual differences in gene-specific methylation in human brain
We have observed extensive interindividual differences in DNA methylation of 8590 CpG
sites of 6229 genes in 153 human adult cerebellum samples, enriched in CpG island" …
sites of 6229 genes in 153 human adult cerebellum samples, enriched in CpG island" …
Sex-biased methylome and transcriptome in human prefrontal cortex
H Xu, F Wang, Y Liu, Y Yu, J Gelernter… - Human molecular …, 2014 - academic.oup.com
Brain function and cognitive performance differ between men and women in some
measures. The phenotypic variation may be partially due to sex differences in epigenomes …
measures. The phenotypic variation may be partially due to sex differences in epigenomes …
[PDF][PDF] Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution
DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
Methylomic trajectories across human fetal brain development
Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …
development. The importance of DNA methylation in fetal brain development is highlighted …