We have previously shown that in mixed cultures of PBL incubation with human rIL-2
induces the rapid expression of IL-1 alpha and IL-1 beta mRNA. Because studies have …

Cultured human monocytes and tissue macrophages exhibit a marked decrease in LPS-
stimulated IL-1 production. Preincubation of monocytes in 100 U/ml IFN-gamma or in 0.25 …

IL-1 gene expression was investigated in human blood mononuclear cells. IL-1 alpha and IL-
1 beta mRNA were induced with LPS or TNF. Kinetic measurements on Northern blots …

Human monocytes may synthesize simultaneously both the agonist IL-1 beta and a specific
receptor antagonist of IL-1 (IL-1ra). These studies examined whether monocyte production …

Human PBMC were cultured in medium containing human rIL-2, and the supernatants and
cell lysates were analyzed for IL-1 alpha and IL-1 beta using specific RIA. IL-2, but not the …

The T cell-derived lymphokine, IL-4, inhibits production of IL-1 beta by normal human
monocytes. To determine whether IL-4 suppresses IL-1 expression by a transcriptional …

Activation of human monocytes with LPS induces coordinate expression of a number of
cytokine genes, including IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, and IL-8. The T cell-derived …

Although recently polymorphonuclear leukocytes (PMN) have been identified as producers
of IL-1 beta in response to LPS and granulocyte/monocyte colony stimulating factor, little is …

IL-1 and TNF-alpha are induced in macrophages by LPS; however, it is unclear whether
similar mechanisms control the expression of both genes. Here, we report on the detection …

We have demonstrated that IL-4 markedly inhibits IL-1 production by highly purified normal
human monocytes. When added to monocyte cultures, IL-4 suppressed LPS-induced IL-1 …