The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

The increased susceptibility of the elderly to infection presents a major challenge to public
health services. An aging immune system is well documented as the cause of increased …

Immunosenescence refers to the inability of an aging immune system to produce an
appropriate and effective response to challenge. This immune dysfunction may manifest as …

An age-related decline in immune responses in the elderly results in greater susceptibility to
infection and reduced responses to vaccination. This decline in immune function affects both …

With increasing age, the ability of the adaptive immune system to respond to vaccines and to
protect from infection declines. In parallel, the production of inflammatory mediators …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …