The role of tumor interaction with stromal components during carcinogenesis is crucial for
the design of efficient cancer treatment approaches. It is widely admitted that tumor hypoxic …

Solid tumors often contain regions with insufficient oxygen delivery, a condition called
hypoxia. Tumor hypoxia is an independent prognostic factor significantly correlated with …

Spontaneous tumors often contain heterogeneous populations of tumor cells with different
tumor-initiating potentials or cancer cell “stemness.” Clonal heterogeneity can be traced to …

Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often
resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced …

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic cell types that reside
within specific areas of tumor microenvironment (TME), and are endowed with self-renewal …

Hypoxia, or gradients of hypoxia, occurs in most growing solid tumors and may result in
pleotropic effects contributing significantly to tumor aggressiveness and therapy resistance …

Tumors are often viewed as unique entities with specific behaviors. However, tumors are a
mixture of differentially evolved subpopulations of cells in constant Darwinian evolution …

Simple Summary Cancers have regions of low oxygen concentration where hypoxia-related
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …

Metastasis is the primary cause of death from cancer due to the spread of disease
throughout the body. Increasing evidence suggests that the hypoxic microenvironment …