Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

Aberrations in the DNA methylation patterns are nowadays recognized as a hallmark of
human cancer One of the most characteristic changes is the hypermethylation of CpG …

DNA methylation, the addition of a methyl group to the carbon-5 position of cytosine
residues, is the only common covalent modification of human DNA and occurs almost …

The unique properties of a cancer cell are acquired through a stepwise accumulation of
heritable changes in the information content of proto‐oncogenes and tumor suppressor …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

Heritable alterations of DNA that do not affect the base pair sequence itself but nevertheless
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

An imbalance of DNA methylation, involving widespread hypomethylation, regional
hypermethylation and increased cellular capacity for methylation, is characteristic of human …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …