Background Placental malaria is a disease linked to the sequestration of Plasmodium
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …

Malaria is undoubtedly the world's most devastating parasitic disease, affecting 300 to 500
million people every year. Some cases of Plasmodium falciparum infection progress to the …

Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …

Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly
infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a …

The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the
infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the …

The adhesion of Plasmodium falciparum-infected erythrocytes (IEs) to chondroitin-4-sulfate
(CSA) via the PfEMP1-CSA parasite ligand domain is correlated with placental malaria in …

Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-
infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated …

Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …

Placental malaria, a serious infection caused by the parasite Plasmodium falciparum, is
characterized by the selective accumulation of infected erythrocytes (IEs) in the placentas of …