Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Two recently published studies published in Science by Daly et al. 1 and Cantuti-Castelvetri
et al. 2 identified neuropilin-1 (NRP1) as an additional cellular mediator which may facilitate …

The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …