The endothelial glycocalyx: new diagnostic and therapeutic approaches in sepsis

L Martin, P Koczera, E Zechendorf… - BioMed research …, 2016 - Wiley Online Library
Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host
response to infection. The endothelial glycocalyx is one of the earliest sites involved during …

[HTML][HTML] Derangement of the endothelial glycocalyx in sepsis

T Iba, JH Levy - Journal of Thrombosis and Haemostasis, 2019 - Elsevier
The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …

[HTML][HTML] Endothelial glycocalyx degradation during sepsis: Causes and consequences

RC Sullivan, MD Rockstrom, EP Schmidt… - Matrix Biology Plus, 2021 - Elsevier
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …

Targeting the endothelial glycocalyx in acute critical illness as a challenge for clinical and laboratory medicine

V Cerny, D Astapenko, F Brettner, J Benes… - Critical Reviews in …, 2017 - Taylor & Francis
The purpose of this manuscript is to review the role of endothelial glycocalyx (EG) in the field
of critical and perioperative medicine and to discuss possible future directions for …

[HTML][HTML] Glycocalyx in endotoxemia and sepsis

MS Goligorsky, D Sun - The American journal of pathology, 2020 - Elsevier
Along with the recognition of a crucial role played by endothelial dysfunction secondarily
igniting cardiovascular, pulmonary, and renal complications, investigational focus has …

Endothelial glycocalyx degradation in critical illness and injury

EK Patterson, G Cepinskas, DD Fraser - Frontiers in Medicine, 2022 - frontiersin.org
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …

Decreased endothelial glycocalyx thickness is an early predictor of mortality in sepsis

DMH Beurskens, ME Bol, T Delhaas… - … and intensive care, 2020 - journals.sagepub.com
Microcirculatory alterations play an important role in the early phase of sepsis. Shedding of
the endothelial glycocalyx is regarded as a central pathophysiological mechanism causing …

Endothelial glycocalyx as a potential theriapeutic target in organ injuries

RN Cao, L Tang, ZY Xia, R Xia - Chinese medical journal, 2019 - mednexus.org
Objective: The endothelial glycocalyx (eGC) is a dynamic and multicomponent layer of
macromolecules found at the surface of vascular endothelium, which is largely …

The endothelial glycocalyx: structure and function in health and critical illness

S Gaudette, D Hughes, M Boller - Journal of veterinary …, 2020 - Wiley Online Library
Objective To conduct a narrative review of the current literature in reference to the structure
and function of the endothelial glycocalyx (EG) and its contribution to the pathophysiology of …

Glycocalyx and sepsis-induced alterations in vascular permeability

C Chelazzi, G Villa, P Mancinelli, AR De Gaudio… - Critical care, 2015 - Springer
Endothelial cells line the inner portion of the heart, blood vessels, and lymphatic vessels; a
basal membrane of extracellular matrix lines the extraluminal side of endothelial cells. The …