[HTML][HTML] Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition
The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …
effect remains elusive. One potential contribution are differences in the glycosylation of …
ACE2 glycans preferentially interact with SARS-CoV-2 over SARS-CoV
We report a distinct difference in the interactions of the glycans of the host-cell receptor,
ACE2, with SARS-CoV-2 and SARS-CoV S–protein receptor-binding domains (RBDs). Our …
ACE2, with SARS-CoV-2 and SARS-CoV S–protein receptor-binding domains (RBDs). Our …
[HTML][HTML] Site-specific glycosylation patterns of the SARS-CoV-2 spike protein derived from recombinant protein and viral WA1 and D614G strains
Y Tian, LM Parsons, E Jankowska, JF Cipollo - Frontiers in chemistry, 2021 - frontiersin.org
The SARS-CoV-2 spike protein is heavily glycosylated, having 22 predicted N-glycosylation
sites per monomer. It is also O-glycosylated, although the number of O-glycosites is less …
sites per monomer. It is also O-glycosylated, although the number of O-glycosites is less …
Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2
The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …
[HTML][HTML] Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor
The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind
to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and …
to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and …
[HTML][HTML] ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner
A Isobe, Y Arai, D Kuroda, N Okumura, T Ono… - Communications …, 2022 - nature.com
SARS-CoV-2 has evolved continuously and accumulated spike mutations with each variant
having a different binding for the cellular ACE2 receptor. It is not known whether the …
having a different binding for the cellular ACE2 receptor. It is not known whether the …
Glycosylation in SARS-CoV-2 variants: A path to infection and recovery
Glycan is an essential molecule that controls and drives life in a precise direction. The
paucity of research in glycobiology may impede the significance of its role in the pandemic …
paucity of research in glycobiology may impede the significance of its role in the pandemic …
Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike
AR Mehdipour, G Hummer - Proceedings of the National …, 2021 - National Acad Sciences
Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2
(ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the …
(ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the …
[HTML][HTML] Inhibition of SARS-CoV-2 viral entry upon blocking N-and O-glycan elaboration
The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary
receptor ACE2 are extensively glycosylated. The impact of this post-translational …
receptor ACE2 are extensively glycosylated. The impact of this post-translational …
[HTML][HTML] Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19
DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …