Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents

C Congiu, V Onnis - Bioorganic & medicinal chemistry, 2013 - Elsevier
We have designed, synthesized, and evaluated as potential antitumor agents a series of 2-
hydroxybenzylidene derivatives of the N-(2-trifluoromethylpiridyn-4-yl) anthranilic acid …

Synthesis and biological evaluation of novel aryloxyacetic acid hydrazide derivatives as anticancer agents

S Şenkardeş, Ö Erdoğan, Ö Çevik… - Synthetic …, 2021 - Taylor & Francis
In our continuing search for new anticancer agents, herein we report the synthesis of 2-(4-
chloro-3-methylphenoxy)-N'-[(aryl) methylidene] acetohydrazides 3a–j and the evaluation of …

Synthesis and anti-tumor evaluation of novel hydrazide-hydrazone derivatives

WW Wardakhan, NN EL-SAYED, RM Mohareb - Acta pharmaceutica, 2013 - hrcak.srce.hr
Sažetak The reaction of cyclopentanone with cyanoacetylhydrazine gave the 2-cyano-2-
cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the …

Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action

X Yu, L Shi, S Ke - Bioorganic & medicinal chemistry letters, 2015 - Elsevier
A series of novel acylhydrazone derivatives were designed, synthesized and evaluated for
their potential cytotoxic effects against human cancer cell lines. The preliminary results …

Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives

MT Cocco, C Congiu, V Lilliu, V Onnis - Bioorganic & medicinal chemistry, 2006 - Elsevier
A new series of 2-amino-6-(2-alkyl or arylidenehydrazinyl)-4-(dialkylamino) pyrimidine-5-
carbonitriles, 5–24, were synthesized in satisfactory overall yield, using 2-amino-4 …

Design, Synthesis, and In Vitro Antiproliferative Screening of New Hydrazone Derivatives Containing cis-(4-Chlorostyryl) Amide Moiety

T Al-Warhi, LS Alqahtani, M Abualnaja, S Beigh… - Symmetry, 2022 - mdpi.com
Hydrazones are regarded as a distinctive category of organic compounds because of their
tremendous characteristics and potential uses in analytical, chemical, and medicinal …

New class of potent antitumor acylhydrazone derivatives containing furan

Z Cui, Y Li, Y Ling, J Huang, J Cui, R Wang… - European journal of …, 2010 - Elsevier
A pair of chemical isomeric structures of N-acylhydrazone compounds I and II were
designed and synthesized. The reaction was carried out with high diastereoselectivity to …

Cancer cell growth inhibition by aroylhydrazone derivatives

I Iliev, D Kontrec, R Detcheva, M Georgieva… - Biotechnology & …, 2019 - Taylor & Francis
Hydrazones have versatile properties that make them promising for a range of possible
applications. In this study, we examined a library of 17 aroylhydrazones derived from …

Synthesis, Structure−Activity Relationships, and Antitumor Studies of 2-Benzoxazolyl Hydrazones Derived from Alpha-(N)-acyl Heteroaromatics

J Easmon, G Pürstinger, KS Thies… - Journal of Medicinal …, 2006 - ACS Publications
Recently we have described the antitumor activities of 2-benzoxazolylhydrazones derived
from 2-formyl and 2-acetylpyridines. In search of a more efficacious analogue, compounds in …

Synthesis, characterization and cytotoxic activity of new salicylaldehyde benzoylhydrazone derivatives as potential anti-proliferative agents

B Nikolova-Mladenova, N Halachev… - …, 2011 - thieme-connect.com
Three new hydrazones, derivatives of salicylaldehyde benzoylhydrazone, were synthesized
as potential anti-proliferative compounds. The structure of the new compounds was …