Accumulation of inflammatory microglia in Alzheimer's senile plaques is a hallmark of the
innate response to β-amyloid fibrils and can initiate and propagate neurodegeneration …

β-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's
disease and has recently been identified in plaques of another chronic inflammatory …

A pathological hallmark of Alzheimer's disease is the senile plaque, composed of β-amyloid
fibrils, microglia, astrocytes, and dystrophic neurites. We reported previously that class A …

Abstract Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein
expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both …

CD36 is a membrane protein with wide distribution in the human body, is enriched in the
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …

Although deposition of amyloid β‐peptide (Aβ) as Aβ plaques involves activation of
microglia‐mediated inflammatory responses, activated microglia ultimately fail to clear Aβ …

Senile plaques found in the Alzheimer's disease brain are foci of local inflammatory
reactions mediated by plaque-associated microglia. The interaction of microglia with …

The self-association of proteins to form amyloid fibrils has been implicated in the
pathogenesis of a number of diseases including Alzheimer's, Parkinson's, and Creutzfeldt …

Chronic neuroinflammatory processes including glial activation may play a role in the
pathogenesis of Alzheimer's disease (AD). The immune and inflammatory mediator CD40 …

Genome‐wide association studies demonstrated that polymorphisms in the CD33/sialic acid‐
binding immunoglobulin‐like lectin 3 gene are associated with late‐onset Alzheimer's …