Advances in simulation and optimization technologies coupled with the continued growth in
computing power now increasingly pave the way for the development of advanced model …

Current advances in computer-aided chemical process design and synthesis take
advantage of surrogate modelling and superstructure optimization techniques …

Simulation-based optimization models are widely applied to find optimal operating
conditions of processes. Often, computational challenges arise from model complexity …

Effective decision-making is essential for minimizing the environmental footprint while
strengthening the competitiveness of the chemical industry. This paper proposes a …

In principle, optimization‐based “superstructure” methods for process synthesis can be more
powerful than sequential‐conceptual methods as they account for all complex interactions …

Uncertainties are widespread in the optimization of process systems, such as uncertainties
in process technologies, prices, and customer demands. In this paper, we review the basic …

Plant availability and operating uncertainties are critical considerations for the design and
operation of chemical processes as they directly impact service level and economic …

The objective of this paper is to present a new process synthesis tool to systematically
synthesize, design, and evaluate plant layouts for early-stage design/retrofit of wastewater …

Chemical plant design and optimisation have proven to be challenging due to the
uncertainty in real-world systems. Research to date has mostly assumed that the system …

In this work, we present a framework to support designers in the early-stage screening and
design of chemical processes under uncertainty. The suggested framework is a stepwise …