▪ Abstract Discovery of the gene encoding the protein dystrophin delineated not only the
cause of Duchenne dystrophy but also an expanding family of at least eight different …

Duchenne muscular dystrophy is the most prevalent and severe form of human muscular
dystrophy. Investigations into the molecular basis for Duchenne muscular dystrophy were …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Duchenne muscular dystrophy was described in the medical literature in the early 1850s but
the molecular basis of the disease was not determined until the late 1980s. The cloning of …

Duchenne muscular dystrophy was a well‐established medical and genetic enigma by the
1970s. Why was the new mutation rate so high in all world populations? Why were affected …

Duchenne and Becker muscular dystrophies are caused by mutations in the gene encoding
dystrophin, a component of the subsarcolemmal cytoskeleton. Dystrophin-related proteins …

Dystrophin, a protein product of the Duchenne muscular dystrophy gene, is thought to
associate with the muscle membrane by way of a glycoprotein complex which was co …

This book is concerned with advances in research on dystrophin, and how its absence gives
rise to muscular dystrophy. It is the first book to address relationships between the molecular …

During the past year significant progress has been made in understanding how dystrophin
deficiency leads to muscle cell necrosis in Duchenne muscular dystrophy and Becker …

The discovery of the dystrophin gene, whose mutations lead to Duchenne's and Becker's
muscular dystrophy (DMD and BMD), represents the first important landmark by which, in the …