Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility.
Bacteria have evolved various mechanisms to counter the problems imposed by their iron …

Covering: 2000–2006 The ability of bacterial pathogens to obtain iron is essential for their
survival, and the expression of such virulence factors is (in part) essential for establishing …

Pathogenic bacteria require iron for replication within their host. Klebsiella pneumoniae and
other Gram-negative pathogens produce the prototypical siderophore enterobactin (Ent) to …

Most microbial pathogens have a metabolic iron requirement, necessitating the acquisition
of this nutrient in the host. In response to pathogen invasion, the human host limits iron …

Cells of Escherichia coli can derive iron from a variety of chelators (siderophores) in addition
to enterochelin, the catechol derivative excreted by many enteric bacteria. The genetic …

Iron concentrations in the ocean are low enough to limit the growth of marine
microorganisms, which raises questions about the molecular mechanisms these organisms …

Background Bacteria produce small molecule iron chelators, known as siderophores, to
facilitate the acquisition of iron from the environment. The synthesis of more than one …

The knowledge of how organisms fight infections has largely been built upon the ability of
host innate immune molecules to recognize microbial determinants. Although of …

The outer membrane of Gram-negative bacteria functions as a permeability barrier that
protects these bacteria against harmful compounds in the environment. Most nutrients pass …

Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However,
almost all of the host iron is sequestered in iron-containing compounds and proteins, the …