1 Two novel selective 5‐HT6 receptor ligands E‐6801 (6‐chloro‐N‐(3‐(2‐(dimethylamino)
ethyl)‐1H‐indol‐5‐yl) imidazo [2, 1‐b] thiazole‐5‐sulfonamide) and E‐6837 (5‐chloro‐N‐(3 …

This study describes the in vitro characterization of two potent and selective 5‐HT6 receptor
antagonists at the rat and human recombinant 5‐HT6 receptor. In binding assays with [3H] …

1 Chinese hamster ovary (CHO) cells have been reported to be devoid of 5‐HT receptors
and have frequently been used as hosts for the expression of cloned 5‐HT receptors …

A body of evidences suggests that a hydrophobic pocket of the human 5‐HT4 receptor
contributes to the high affinity of some bulky 5‐HT4 ligands. A thorough study of this pocket …

Introduction: Modulation of constitutive activity by the recombinant wild-type human 5-HT6
receptor was investigated with a series of 5-HT6 receptor ligands by monitoring the cAMP …

The antagonist radioligand [3H] GR125743 and the agonist radioligand [3H] 5-HT were
used to investigate the pharmacological characteristics of the G protein uncoupled agonist …

Background and purpose: 5‐HT4 receptor agonists are used therapeutically to treat
disorders of reduced gastrointestinal motility. Since such compounds are evaluated in …

In recent years, considerable research efforts have focused on the role of serotonin in
various pathological states, as well as on the identification of the respective serotonin …

Tegaserod (Zelnorm®) is a potent 5‐hydroxytryptamine4 (5‐HT4) receptor agonist with
clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The …

We have studied the effects of the purportedly selective 5‐HT1A receptor antagonist (+)‐
WAY100135 on electrically stimulated 5‐hydroxytryptamine (5‐HT) efflux in the ventrolateral …