The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Glycosylation is a frequent post-translational modification which results in the addition of
carbohydrate determinants,“glycans”, to cell surface proteins and lipids. These glycan …

Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …

This review focuses on the recent advances in investigations of the role of cell surface
carbohydrates in tumor metastasis. It also summarizes the results of extensive studies of …

Aberrant glycosylation occurs in essen-tially all types of experimental and human cancers,
as has been observed for over 35 years, and many glycosyl epitopes constitute tumor …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this
issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously …

Glycosylation is catalyzed by various glycosyltransferase enzymes which are mostly located
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …