Geniposide protected hepatocytes from acetaminophen hepatotoxicity by down-regulating CYP 2E1 expression and inhibiting TLR 4/NF-κB signaling pathway

S Yang, GE Kuang, R Jiang, S Wu, T Zeng… - International …, 2019 - Elsevier
Acetaminophen (APAP) is a widely used over-the-counter drug for antipyretic and analgesic,
but an overdose will induce acute liver injury. APAP hepatotoxicity has been the most …

[HTML][HTML] Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice

DW Park, H Jeon, JE Kwon, YG Lee, R So… - Toxicological …, 2021 - Springer
Abstract N-acetyl-p-aminophenol (acetaminophen, APAP) is a well-known component of
analgesic and antipyretic monotherapy products. However, exceeding the recommended …

[HTML][HTML] Essential Oil Derived From Eupatorium adenophorum Spreng. Mediates Anticancer Effect by Inhibiting STAT3 and AKT Activation to Induce Apoptosis in …

H Chen, B Zhou, J Yang, X Ma, S Deng… - Frontiers in …, 2018 - frontiersin.org
Eupatorium adenophorum Spreng.(EA) is a well-known noxious invasive species. Gas
chromatography-mass spectrometry (GC-MS) analysis revealed that the essential oil derived …

Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen‐induced acute liver damage by reducing cell death and oxidative stress in mouse experimental …

LC Liu, CJ Wang, CC Lee, SC Su… - Journal of the …, 2010 - Wiley Online Library
Abstract BACKGROUND: Acetaminophen (AAP)‐induced oxidative stress can cause cell
death to induce liver damage. The antioxidant effect of Hibiscus sabdariffa L.(HS) was …

Sesamin Protects against APAP‐Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal …

H Du, S Tong, G Kuang, X Gong… - Journal of …, 2023 - Wiley Online Library
Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in
severe cases by triggering an inflammatory response and oxidative stress. Sesamin has …

Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice

H Gungor, M Ekici, MB Ates - Drug and Chemical Toxicology, 2023 - Taylor & Francis
Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of
Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen …

Piceatannol mediated modulation of oxidative stress and regeneration in the liver of endotoxemic mice

V Kiliç - Journal of medicinal food, 2019 - liebertpub.com
Liver plays a pivotal role in host defense mechanisms related to endotoxemia. However,
liver dysfunction often occurs in early sepsis. This study investigated the hepatoprotective …

Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma

B Pan, W Pan, Z Lu, C Xia - Evidence‐Based Complementary …, 2021 - Wiley Online Library
Background. The number of hepatocellular carcinoma (HCC) cases worldwide has
increased significantly. As a traditional Chinese medicine (TCM) with a long history, Ecliptae …

[HTML][HTML] Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro

Z Tian, H Jia, Y Jin, M Wang, J Kou… - Food & Nutrition …, 2019 - ncbi.nlm.nih.gov
Background 'Bianliang ziyu', a famous chrysanthemum variety commonly planted in Kaifeng,
China, is often consumed by local residents. However, the hepatoprotective effects of …

Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways

Z Peng, X Gong, Y Yang, L Huang, Q Zhang… - International …, 2017 - Elsevier
Quercetin is regarded as a potential hepatoprotective agent in the treatment of acute liver
injury. However, the underlying mechanism of how quercetin to protect against …