The aim of this study was to investigate the hepatotoxic effect and its underlying mechanism
of aloe emodin (AE). AE was docked with the targets of NF-κB inflammatory pathway and …

Natural product lingenol, a purified diterpenoid compound derived from the root of
Euphorbia kansui, exerts serious hepatotoxicity; however, the molecular mechanisms …

Nobiletin and tangeretin are polymethoxy flavonoids (PMFs), found in rich quantities in the
peel of citrus fruits. In the present study, we assessed the biological effect of the PMFs on …

Acetaminophen (APAP) is widely used as a safety analgesic and antipyretic agent. Although
considered safe at therapeutic doses, overdose of APAP can cause acute liver injury that is …

Endotoxemia is a common event in alcoholic liver disease. Elevated intestinal permeability
is the major factor involved in the mechanism of alcoholic endotoxemia and the …

This experiment was to explore the possible defensive properties and potential molecular
mechanisms of Camellia japonica (CJ) against APAP-stimulated acute liver failure (ALF) in …

Background: Immunological liver injury (ILI) is a common liver disease and lacks potent
drugs for treatment. Artemisia argyi Lévl. et Vant.(A. argyi), a medicinal and edible …

Elephantopus scaber has been traditionally used as liver tonic. However, the protective
effect of E. scaber on ethanol‐induced liver damage is still unclear. In this study, we have …

The liver is vulnerable to oxidative stress-induced damage, which leads to many diseases,
including alcoholic liver disease (ALD). Liver disease endanger people's health, and the …

Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …