Background Cancellous bone can act as a delivery vehicle for vancomycin without
impairment of graft incorporation. However, local and systemic antibiotic levels, biological …

Vancomycin-supplemented allografts provide biological restoration of bone stock and sound
fixation with a low incidence of re-infection. Experimental incorporation of these grafts is …

Background The purpose of this clinical investigation was to evaluate the systemic
bioavailability of antibiotics from bone cement after implantation. This was done by …

Background The use of antibiotic-loaded cement has become a well-accepted method to
develop high local antibiotic concentrations in revision surgery of infected arthroplasty. A …

We studied the bioactivity of vancomycin and tobramycin eluted from methylmethacrylate
bone cement. Aliquots of the drainage were obtained at 1, 6, 12 and 24 hours following total …

Bone allografts can store and release high levels of vancomycin. We present our results of a
two-stage treatment for infected hip arthroplasty with acetabular and femoral impaction …

We explored the role of vancomycin-supplemented cancellous bone allografts in hip
revision surgery. We evaluated the incorporation of these allografts in 18 pigs' radiographs …

The addition of antibiotic to cement is a frequent practice in aseptic revision hip surgery
There is concern about adding vancomycin to cement due to potential effects on mechanical …

Aim: Evaluation of the delivery of gentamicin and vancomycin from polymethylmethacrylate
(PMMA) spacers before and after implantation for the treatment of total hip replacement …

Background: Periprosthetic joint infection following hip and knee arthroplasty leads to poor
outcomes and exorbitant costs. Topical vancomycin powder has been shown to decrease …