The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator
of cell growth. Recent experimental results suggest that RB1 may exert its growth …

The retinoblastoma gene (RB1) is a recessive oncogene implicated in a number of human
tumors. Although the RB1 gene is expressed in most proliferating cells, there is considerable …

The retinoblastoma gene product, pRB, regulates cell proliferation by binding to and
inhibiting the activity of key growth promoting proteins. Several cellular proteins have been …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Although the precise function of the retinoblastoma gene product, pl lO P~ 1, remains
unknown, recent data suggest that it plays a role in the control of ceUular proliferation by …

A class of cellular genes in which loss-of-function mutations are tumorigenic has been
proposed. Such genes would normally act to suppress the cancer phenotype at the cellular …

The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene
products. Its loss during the genesis of many human tumours, its inactivation by several DNA …

The retinoblastoma gene (RB) is the prototype of the tumor suppressor genes, which play
critical roles in the genesis of cancer in humans. Mouse models created through gene knock …

The retinoblastoma gene is the prototype of the tumor suppressor genes, which play critical
roles in the genesis of cancer in humans. Although the precise function of the retinoblastoma …

Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb)
has been extensively studied. Numerous biochemical and genetic studies have elucidated …