Perivascular spaces contribute to cognition beyond other small vessel disease markers

BS Passiak, D Liu, HA Kresge, FE Cambronero… - Neurology, 2019 - AAN Enterprises
Objective To cross-sectionally relate multiple small vessel disease (SVD) neuroimaging
markers to cognition among older adults. Methods Vanderbilt Memory & Aging Project …

Association of dilated perivascular spaces with cognitive decline and incident dementia

M Paradise, JD Crawford, BCP Lam, W Wen… - Neurology, 2021 - AAN Enterprises
Objective To determine whether severe perivascular space (PVS) dilation is associated with
longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we …

Large perivascular spaces visible on magnetic resonance imaging, cerebral small vessel disease progression, and risk of dementia: the age, gene/environment …

J Ding, S Sigurðsson, PV Jónsson, G Eiriksdottir… - JAMA …, 2017 - jamanetwork.com
Importance With advancing age, an increased visibility of perivascular spaces (PVSs) on
magnetic resonance imaging (MRI) is hypothesized to represent impaired drainage of …

Association between enlarged perivascular spaces and cognition in a memory clinic population

YM Choe, H Baek, HJ Choi, MS Byun, D Yi, BK Sohn… - Neurology, 2022 - AAN Enterprises
Background and Objectives Although enlarged perivascular spaces (EPVS) have been
suggested as an emerging measure of small vessel disease (SVD) in the brain, their …

Basal ganglia enlarged perivascular spaces are linked to cognitive function in patients with cerebral small vessel disease

M Huijts, A Duits, J Staals, AA Kroon… - Current …, 2014 - ingentaconnect.com
Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD)
and have been related to cSVD severity. A higher number of EPVS were related to …

[HTML][HTML] Total MRI load of cerebral small vessel disease and cognitive ability in older people

J Staals, T Booth, Z Morris, ME Bastin, AJ Gow… - Neurobiology of …, 2015 - Elsevier
Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the
association between the combined presence of magnetic resonance imaging (MRI) features …

Total cerebral small vessel disease score and cognitive performance in community‐dwelling older adults. Results from the Atahualpa Project

VJ Del Brutto, JG Ortiz, OH Del Brutto… - … journal of geriatric …, 2018 - Wiley Online Library
Objective Cerebral small vessel disease (SVD) is inversely associated with cognitive
performance. However, whether the total SVD score is a better predictor of poor cognitive …

Lacunar infarcts, but not perivascular spaces, are predictors of cognitive decline in cerebral small-vessel disease

P Benjamin, S Trippier, AJ Lawrence, C Lambert… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Cerebral small-vessel disease is a major cause of cognitive
impairment. Perivascular spaces (PvS) occur in small-vessel disease, but their relationship …

Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: a multicenter prospective cohort study

MK Georgakis, R Fang, M Düring… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction It remains unknown whether the global small vessel disease (SVD) burden
predicts post‐stroke outcomes. Methods In a prospective multicenter study of 666 ischemic …

Impact of strategically located white matter hyperintensities on cognition in memory clinic patients with small vessel disease

JM Biesbroek, NA Weaver, S Hilal, HJ Kuijf, MK Ikram… - PLoS …, 2016 - journals.plos.org
Background and Purpose Studies on the impact of small vessel disease (SVD) on cognition
generally focus on white matter hyperintensity (WMH) volume. The extent to which WMH …