[HTML][HTML] Novel sars-cov-2 receptors: asgr1 and kremen1
M Hoffmann, S Pöhlmann - Cell research, 2022 - nature.com
The interaction of the SARS-CoV-2 spike protein with the cellular receptor ACE2 is believed
to be essential for viral entry into host cells. In a recent paper published in Cell Research, Gu …
to be essential for viral entry into host cells. In a recent paper published in Cell Research, Gu …
[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …
has infected more than 46 million people worldwide, killing over one million two hundred …
[HTML][HTML] Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
[HTML][HTML] ACE2-independent alternative receptors for SARS-CoV-2
S Lim, M Zhang, TL Chang - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent
of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public …
of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public …
[HTML][HTML] Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
Y Gu, J Cao, X Zhang, H Gao, Y Wang, J Wang, J He… - Cell research, 2022 - nature.com
Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
[HTML][HTML] Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design
X Xia - Viruses, 2021 - mdpi.com
The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to
gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …
gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …
[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …
[HTML][HTML] SARS-CoV-2 cellular entry is independent of the ACE2 cytoplasmic domain signaling
T Karthika, J Joseph, VRA Das, N Nair, P Charulekha… - Cells, 2021 - mdpi.com
Recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and-2
initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor …
initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor …
[HTML][HTML] Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract
ME Ortiz, A Thurman, AA Pezzulo, MR Leidinger… - …, 2020 - thelancet.com
Background Zoonotically transmitted coronaviruses are responsible for three disease
outbreaks since 2002, including the current COVID-19 pandemic, caused by SARS-CoV-2 …
outbreaks since 2002, including the current COVID-19 pandemic, caused by SARS-CoV-2 …
[HTML][HTML] Targeting the entry step of SARS-CoV-2: a promising therapeutic approach
J Li, P Zhan, X Liu - Signal transduction and targeted therapy, 2020 - nature.com
A very recent study published in Cell by Hoffmann and coworkers identifies the key proteins
exploited by SARS-CoV-2 to invade cells, and finds some effective therapeutic strategies …
exploited by SARS-CoV-2 to invade cells, and finds some effective therapeutic strategies …