Concomitant white matter (WM) brain pathology is often present in patients with mild
cognitive impairment (MCI) and Alzheimer's disease (AD). Cognitive effects of WM pathology …

Vascular risk factors (VRFs) have been associated with clinically diagnosed Alzheimer
disease (AD), but few studies have examined the association between VRF and AD …

Objective To investigate brain amyloid pathology in a dementia-risk population defined as
cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with …

Background: The long-term course of cognitive impairments secondary to cardiovascular
disease (CVD) is unclear. In this study, we prospectively investigated the temporal pattern …

Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the
association between the combined presence of magnetic resonance imaging (MRI) features …

BACKGROUND AND PURPOSE: The importance of executive dysfunction is increasingly
recognized in the dementia syndrome. Although executive dysfunction has been associated …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

Background and Purpose—We sought to determine the predictive value of magnetic
resonance imaging measures of vascular disease (white matter hyperintensities [WMHs] …

Background and Purpose—Although a strong relationship has been established between
vascular disease and cognitive decline, the current challenge is to identify vascular risk …

Background There are conflicting data showing that stroke is associated with a higher risk of
dementia and a more severe decline in persons with cognitive impairment. However, it …