Background: The 2 50 k Da r etinoblastoma bi nding pr otein 6 (RBBP6) was cloned over a
decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In …

Abstract Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has
been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been …

Retinoblastoma Binding Protein 6 (RBBP6) has been implicated in the apoptotic pathway
and regulation of the cell cycle through its interaction with p53, Rb and YB1 and …

RBBP6 is a 250 kDa eukaryotic protein known to be a negative regulator of p53 and
essential for embryonic development. Furthermore, RBBP6 is a critical element in …

Apoptosis is normally kept under strict control by a range of regulators and inhibitors, and
loss of this regulation strongly directs tumour progression. The novel RBBP6 gene has been …

RBBP6 is a novel gene encoding splicing-associated proteins. There are 3 protein isoforms
(isoforms 1-3). RBBP6 isoforms 1 has been shown to interact with both p53 and Rb. It also …

Introduction Breast cancer is the most common malignancy amongst women and has a
higher incidence rate than lung cancer. Its tumor progression partially results from …

Overexpression of RBBP6 in cancers of the colon, lung, and esophagus makes it a potential
target in anticancer therapy. This is especially important because RBBP6 associates with the …

Retinoblastoma binding protein 6 (RBBP6) interacts with both p53 and pRb, and has been
identified as an E3 ubiquitin ligase due to the presence of a RING finger domain. RBBP6 …

Retinoblastoma binding protein 6 (RBBP6) plays an important role in chaperone-mediated
ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic …