Diversification of retinoblastoma protein function associated with cis and trans adaptations
Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …
cell cycle control, among other functions. Although most metazoan genomes encode a …
Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein
The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …
including cell cycle, senescence, and differentiation. The activity and stability of these …
Evidence for Autoregulation and Cell Signaling Pathway Regulation From Genome-Wide Binding of the Drosophila Retinoblastoma Protein
The retinoblastoma (RB) tumor suppressor protein is a transcriptional cofactor with essential
roles in cell cycle and development. Physical and functional targets of RB and its paralogs …
roles in cell cycle and development. Physical and functional targets of RB and its paralogs …
Distinct developmental expression of Drosophila retinoblastoma factors
SA Keller, Z Ullah, MS Buckley, RW Henry… - Gene expression …, 2005 - Elsevier
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis
RBf2 is a recently evolved retinoblastoma family member in Drosophila that differs from
RBf1, especially in the C-terminus. To investigate whether the unique features of RBf2 …
RBf1, especially in the C-terminus. To investigate whether the unique features of RBf2 …
Paradoxical instability–activity relationship defines a novel regulatory pathway for retinoblastoma proteins
The Retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins
play central roles in cell cycle control and development, and the regulatory networks …
play central roles in cell cycle control and development, and the regulatory networks …
Regulation of cell lineage specification by the retinoblastoma tumor suppressor
SX Skapek, YR Pan, EYH Lee - Oncogene, 2006 - nature.com
Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator
of the G 1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and …
of the G 1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and …
Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes
In higher eukaryotes, the Retinoblastoma and E2F families of proteins control the
transcription of a large number of target genes. Here, we have mutated the second …
transcription of a large number of target genes. Here, we have mutated the second …
Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells
MK Popova, W He, M Korenjak… - Journal of cell …, 2011 - journals.biologists.com
Retinoblastoma tumor suppressor protein (pRb) regulates various biological processes
during development and tumorigenesis. Although the molecular mechanism by which pRb …
during development and tumorigenesis. Although the molecular mechanism by which pRb …
Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting
The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human
tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family …
tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family …