Background: Previous reports have demonstrated the antihypertensive efficacy of high
doses of spironolactone in subjects with primary aldosteronism and, to a lesser degree …

Our objective was to estimate the effect of addition of low-dose spironolactone to previous
antihypertensive therapy in patients with resistant hypertension. Patients had 25 to 50 mg of …

Methods We have conducted an open observational study of the use of spironolactone 25–
50 mg in the management of patients with resistant hypertension. This drug was …

There is currently limited data on which drug should be used to improve blood pressure (BP)
control in patients with resistant hypertension. This study was designed to assess the effect …

Background: Hypertension is resistant to pharmacologic therapy in 5% to 10% of patients.
The current study tested whether addition of spironolactone to the treatment of patients with …

The role of spironolactone in resistant hypertension management is unclear. The aim of this
prospective trial was to evaluate the antihypertensive effect of spironolactone in patients with …

Effect of Spironolactone in Resistant Arterial Hypertension:... : Medicine Effect of
Spironolactone in Resistant Arterial Hypertension: A Randomized, Double-Blind, Placebo-Controlled …

Objective The efficacy of add-on use of spironolactone in patients with resistant
hypertension has been investigated in several small studies. We performed this meta …

This study was designed to assess the effect of additional spironolactone on blood pressure
in patients with resistant hypertension. MEDLINE, EMBASE, and Cochrane Library were …

Background—There is continuing variation in diagnosis and estimated prevalence of
primary hyperaldosteronism. The higher estimates encourage search for adrenal adenomas …