Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

The major energy generator in the cell–mitochondria produce reactive oxygen species as a
by-product of a number of enzymatic reactions and the production of ATP. Emerging …

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative
diseases dominating in Alzheimer's disease (AD), Parkinson's disease (PD), and …

The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

Oxidative stress has long been linked to neuronal cell death that is associated with certain
neurodegenerative conditions. Whether it is a primary cause or merely a downstream …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

A growing body of evidence suggests that mitochondrial abnormalities are involved in aging
and in age-related neurodegenerative diseases as well as cancer, diabetes, and several …

Although the etiology for many neurodegenerative diseases is unknown, the common
findings of mitochondrial defects and oxidative damage posit these events as contributing …

Oxidative stress is among the major causes of toxicity due to interaction of Reactive Oxygen
Species (ROS) with cellular macromolecules and structures and interference with signal …