Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have
previously been shown to segregate with early onset Alzheimer's disease in some families …

A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …

Since the report of a double mutation at codons 670 and 671 of the amyloid precursor
protein (APP) gene identified in two Swedish families with clinically diagnosed Alzheimer's …

Mutations within the β–amyloid precursor protein gene cosegregate with the early–onset
form of familial Alzheimer's Disease (FAD). It is not known how these mutations result in …

A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …

Following reports of mutations of codon 717 in exon 17 of the amyloid precursor protein
(APP) gene in early–onset familial Alzheimer's disease, we screened exon 17 for new …

B--amyloid deposition is central to the pathology ofboth Alzheimer's disease (AD) and some
forms of cerebral congophilicangiopathy (CA)'. In AD, B--amyloid deposition is found …

We report a novel mutation in the amyloid precursor protein gene (APP I716V) which
probably leads to familial early onset Alzheimer's disease with an onset age in the mid 50s …

We sequenced the entire coding region of the amyloid precursor protein (APP) genes of 11
unrelated patients with Japanese familial Alzheimer's disease (FAD) in order to determine …

Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …