Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma
CIC-DUX4 is a rare and understudied transcription factor fusion oncoprotein. CIC-DUX4 co-
opts native gene targets to drive a lethal form of human sarcoma. The molecular …
opts native gene targets to drive a lethal form of human sarcoma. The molecular …
CIC-DUX4 chromatin profiling reveals new epigenetic dependencies and actionable therapeutic targets in CIC-rearranged sarcomas
Simple Summary CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue
tumor predominantly affecting young adults for which the only oncogenic driver is the CIC …
tumor predominantly affecting young adults for which the only oncogenic driver is the CIC …
[HTML][HTML] Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models
PG Hendrickson, KM Oristian, MKR Browne… - Research …, 2023 - ncbi.nlm.nih.gov
Abstract CIC-DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small
round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and …
round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and …
CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs
RA Okimoto, W Wu, S Nanjo, V Olivas… - The Journal of …, 2019 - Am Soc Clin Investig
Transcription factor fusion genes create oncoproteins that drive oncogenesis and represent
challenging therapeutic targets. Understanding the molecular targets by which such fusion …
challenging therapeutic targets. Understanding the molecular targets by which such fusion …
[HTML][HTML] CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression
SC Smith, D Buehler, EYK Choi, JB McHugh… - Modern Pathology, 2015 - Elsevier
Recent molecular advances have identified a novel, clinically aggressive subgroup of
undifferentiated round cell sarcomas defined molecularly by oncogenic fusion of the gene …
undifferentiated round cell sarcomas defined molecularly by oncogenic fusion of the gene …
Cic-rearranged sarcomas: an intriguing entity that may lead the way to the comprehension of more common cancers
C Mancarella, M Carrabotta, L Toracchio, K Scotlandi - Cancers, 2022 - mdpi.com
Simple Summary In this review, we aim to summarize the current clinical and biological
knowledge for patients affected by a rare soft-tissue sarcoma, the CIC-rearranged sarcoma …
knowledge for patients affected by a rare soft-tissue sarcoma, the CIC-rearranged sarcoma …
Spontaneous expression of the CIC:: DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice
PG Hendrickson, KM Oristian, MKR Browne, L Luo… - Oncogene, 2024 - nature.com
Abstract CIC:: DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small
round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and …
round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and …
Nuclear DUX4 immunohistochemistry is a highly sensitive and specific marker for the presence of CIC::DUX4 fusion in CIC‐rearranged sarcomas: a study of 48 …
RT Macedo, V Baranovska‐Andrigo, T Pancsa… - …, 2024 - Wiley Online Library
Aims CIC‐rearranged sarcomas (CRS) are clinically aggressive undifferentiated round cell
sarcomas (URCS), commonly driven by CIC:: DUX4. Due to the repetitive nature of DUX4 …
sarcomas (URCS), commonly driven by CIC:: DUX4. Due to the repetitive nature of DUX4 …
Round cell sarcoma with CIC‐DUX4 gene fusion: Discussion of the distinctive cytomorphologic, immunohistochemical, and molecular features in the differential …
I Chebib, VY Jo - Cancer cytopathology, 2016 - Wiley Online Library
BACKGROUND Undifferentiated round cell sarcomas are a heterogeneous group, and
include tumors that resemble the Ewing sarcoma family. Although a subset defined by …
include tumors that resemble the Ewing sarcoma family. Although a subset defined by …
CIC-DUX4 sarcomas
M Brahmi, H Vanacker, N Macagno… - Current Opinion in …, 2022 - journals.lww.com
CIC-DUX4 sarcomas : Current Opinion in Oncology CIC-DUX4 sarcomas : Current Opinion in
Oncology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts …
Oncology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts …
相关搜索
- undifferentiated sarcoma cic dux4
- transcriptional response cic dux4
- cell sarcoma transcriptional response
- chromatin profiling cic dux4
- fusion oncoprotein cic dux4
- oncoprotein expression undifferentiated sarcoma
- wee1 kinase undifferentiated sarcoma
- transgenic zebrafish cic dux4
- wee1 kinase cic dux4
- therapeutic vulnerability cic dux4
- therapeutic vulnerability undifferentiated sarcoma
- mapk erk cic dux4
- mapk erk undifferentiated sarcoma
- cell sarcoma transgenic zebrafish
- cell sarcoma cic dux4
- sarcoma metastasis cic dux4