Background The response of mesothelial cells to surgical trauma and bacterial
contamination is poorly defined. We have recently shown that CO 2 pneumoperitoneum …

Background: Minimally invasive techniques are increasingly applied to children with
malignant tumors. We showed previously that CO 2 used for pneumoperitoneum modulates …

Purpose: It has been reported that CO 2 gas, used to establish a pneumoperitoneum during
laparoscopy, affects the behavior of tumor cells. The proto-oncogenes c-myc and HMGB-1 …

Background Minimally invasive techniques are increasingly used for biopsy and resection of
neuroblastoma, but the impact on the behavior of spilled tumor cells is unknown. We aimed …

Background Experimental and clinical studies, have suggested that the CO 2
pneumoperitoneum influences the development of intraabdominal tumor dissemination and …

Background Conventional laparoscopic surgery uses CO 2 that is dry and cold, which can
damage peritoneal surfaces. It is speculated that disseminated cancer cells may adhere to …

Background Laparoscopy is becoming more common in neonates. However, concerns
remain about the impact of the carbon-dioxide (CO 2)-insufflation over the neonatal brain …

Background: Whether laparoscopy with CO 2 pneumoperitoneum affects the peritoneal
metastasis of gastric cancer is a pressing question. In light of the important impact change in …

The ablative role of minimally invasive surgery (MIS) in neuroblastoma (NB) is still
controversial due to the possible CO₂ pneumoperitoneum side-effects on tumor …

Background. Port-site recurrences have often been reported after laparoscopic surgery for
malignant disease, and the pathogenesis is unknown. Whether different gases used to …