In our previous paper, we have reported that some 8‐alkoxy‐1, 3‐dimethyl‐1H‐purine‐2, 6
(3H, 7H)‐dione derivatives possessed high affinity and displayed agonistic activity for the …

抄録 It has been reported that an acetone extract of ginger and its fractions have anti-5-HT (5-
hydroxytryptamine; serotonin) effects. In the present study, guinea pig ileum, rat stomach …

A series of esters and amides of l-alkyl-2-oxo-1, 2-dihydroquinoline-4-carboxylic acid or 2-
alkoxy-quinoline-4-carboxylic acid containing a basic azabicycloalkyl moiety has been …

Abstract Male Sprague-Dawley rats were trained to discriminate the putative 5-HT 1A
receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) from saline in a 2 …

A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and
substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor …

Abstract Rationale 2-([2-(4-cyano-2, 5-dimethoxyphenyl) ethylamino] methyl) phenol (25CN-
NBOH) is structurally similar to N-benzyl substituted phenethylamine hallucinogens currently …

We used an in vitro radioligand receptor binding assay with rat cerebral cortex,
hippocampus and striatum membrane preparations to show that 1-[3 (3, 4 …

Five 2-acylindoIe alkaloids, isolated from the leaves of Pterotahema incon-spicua, were
pharmacologically investigated. The major alkaloids methuenine and 16-epimethuenine …

The ability of a series of compounds to mimic the stimulus properties of 8-hydroxy-2-(di-n-
propylamino) tetralin (8-OH-DPAT) was compared to:(1) the affinity of these compounds for …

oXJs O Page 1 Pergamon Bioorganic & Medicinal Chemist~ Letters, Vol. 5, No. 16, pp. 1853-1856,
1995 Copyright Đ 1995 Elsevier Science Ltd Printed in Great Britain. All rights reserved …