Design and assessment of anti-biofilm peptides: steps toward clinical application

M Dostert, CR Belanger, REW Hancock - Journal of innate immunity, 2019 - karger.com
Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-
threatening infections in humans. At least two-thirds of all clinical infections are biofilm …

Anti-biofilm peptides as a new weapon in antimicrobial warfare

D Pletzer, SR Coleman, REW Hancock - Current opinion in microbiology, 2016 - Elsevier
Highlights•To date no antibiotics have been specifically developed for biofilm infections.•Anti-
biofilm peptides directly address chronic multi-resistant bacterial infections.•They …

[HTML][HTML] Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

EF Haney, MJ Trimble, JT Cheng, Q Vallé… - Biomolecules, 2018 - mdpi.com
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface.
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …

Antibiofilm peptides: potential as broad-spectrum agents

D Pletzer, REW Hancock - Journal of bacteriology, 2016 - Am Soc Microbiol
The treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic
resistance and relatively few novel compounds or strategies under development or entering …

[HTML][HTML] Antibiofilm peptides: overcoming biofilm-related treatment failure

M Dostert, MJ Trimble, REW Hancock - RSC advances, 2021 - pubs.rsc.org
Health leaders and scientists worldwide consider antibiotic resistance among the world's
most dangerous pathogens as one of the biggest threats to global health. Antibiotic …

[HTML][HTML] Synthetic antibiofilm peptides

C De La Fuente-Núñez, MH Cardoso… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Bacteria predominantly exist as multicellular aggregates known as biofilms that are
associated with at least two thirds of all infections and exhibit increased adaptive resistance …

[HTML][HTML] Antimicrobial and antibiofilm peptides

A Di Somma, A Moretta, C Canè, A Cirillo, A Duilio - Biomolecules, 2020 - mdpi.com
The increasing onset of multidrug-resistant bacteria has propelled microbiology research
towards antimicrobial peptides as new possible antibiotics from natural sources …

[HTML][HTML] Broad-spectrum anti-biofilm peptide that targets a cellular stress response

C De la Fuente-Núñez, F Reffuveille, EF Haney… - PLoS …, 2014 - journals.plos.org
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …

Antibiofilm peptides: relevant preclinical animal infection models and translational potential

GGOS Silveira, MDT Torres, CFA Ribeiro… - ACS Pharmacology & …, 2021 - ACS Publications
Biofilm-forming bacteria may be 10–1000 times more resistant to antibiotics than planktonic
bacteria and represent about 75% of bacterial infections in humans. Antibiofilm treatments …

[HTML][HTML] Antibiofilm peptides and peptidomimetics with focus on surface immobilization

A Andrea, N Molchanova, H Jenssen - Biomolecules, 2018 - mdpi.com
Bacterial biofilms pose a major threat to public health, as they are associated with at least
two thirds of all infections. They are highly resilient and render conventional antibiotics …