Individual and Combined Effects of Engineered Peptides and Antibiotics on Pseudomonas aeruginosa Biofilms

B Mishra, G Wang - Pharmaceuticals, 2017 - mdpi.com
Pseudomonas aeruginosa is involved in a variety of difficult-to-treat infections frequently due
to biofilm formation. To identify useful antibiofilm strategies, this article evaluated efficacy of …

Prevention of ESKAPE pathogen biofilm formation by antimicrobial peptides WLBU2 and LL37

Q Lin, B Deslouches, RC Montelaro, YP Di - International journal of …, 2018 - Elsevier
Objectives Bacterial biofilm-dependent infections (eg cystic fibrosis, surgical sites, and
medical implants) are associated with enhanced drug-resistance and are thus difficult to …

Biofilm formation as valuable target to fight against severe chronic infections

C Pecoraro, D Carbone, D Deng… - Current medicinal …, 2022 - ingentaconnect.com
As most countries in the world are struggling to control the COVID-19 pandemic, scientists
should warn that other infective diseases are inevitable, and antibiotic resistance to bacterial …

Action of antimicrobial peptides against bacterial biofilms

M Yasir, MDP Willcox, D Dutta - Materials, 2018 - mdpi.com
Microbes are known to colonize surfaces and form biofilms. These biofilms are communities
of microbes encased in a self-produced matrix that often contains polysaccharides, DNA and …

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

D Pletzer, SC Mansour, REW Hancock - PLoS pathogens, 2018 - journals.plos.org
With the antibiotic development pipeline running dry, many fear that we might soon run out
of treatment options. High-density infections are particularly difficult to treat due to their …

Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …

Biofilms: Survival and defense strategy for pathogens

A Kumar, A Alam, M Rani, NZ Ehtesham… - International Journal of …, 2017 - Elsevier
Studies on biofilm related infections are gaining prominence owing to their involvement in
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …

Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity

H Etayash, Y Qian, D Pletzer, Q Zhang… - Journal of medicinal …, 2020 - ACS Publications
Therapeutic options to treat multidrug resistant bacteria, especially when present in biofilms,
are limited due to their high levels of antibiotic resistance. Here, we report the anti-biofilm …

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

[HTML][HTML] Natural anti-biofilm agents: strategies to control biofilm-forming pathogens

R Mishra, AK Panda, S De Mandal, M Shakeel… - Frontiers in …, 2020 - frontiersin.org
Pathogenic microorganisms and their chronic pathogenicity are significant concerns in
biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident …