Glycosylation in cancer: mechanisms and clinical implications
Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …
[HTML][HTML] Hallmarks of glycosylation in cancer
J Munkley, DJ Elliott - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
development and progression. Glycans have roles in cancer cell signalling, tumour cell …
Altered glycosylation in cancer: A promising target for biomarkers and therapeutics
Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …
Glycosylation in the era of cancer-targeted therapy: where are we heading?
S Mereiter, M Balmaña, D Campos, J Gomes, CA Reis - Cancer cell, 2019 - cell.com
This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …
influence in the current approaches of targeted cancer therapies in the clinical setting. The …
The sweet side of immune evasion: role of glycans in the mechanisms of cancer progression
AFFR Nardy, L Freire-de-Lima… - Frontiers in …, 2016 - frontiersin.org
Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …
fundamental role in several physiopathological processes, including cell differentiation …
Glycosylation changes in cancer
Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-
known markers of tumor progression. This chapter discusses glycan biosynthetic pathways …
known markers of tumor progression. This chapter discusses glycan biosynthetic pathways …
Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics
N Taniguchi, Y Kizuka - Advances in cancer research, 2015 - Elsevier
Glycosylation is catalyzed by various glycosyltransferase enzymes which are mostly located
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …
Glycans in cancer and inflammation—potential for therapeutics and diagnostics
DH Dube, CR Bertozzi - Nature reviews Drug discovery, 2005 - nature.com
Abstract Changes in glycosylation are often a hallmark of disease states. For example,
cancer cells frequently display glycans at different levels or with fundamentally different …
cancer cells frequently display glycans at different levels or with fundamentally different …
Targeting glycosylation: a new road for cancer drug discovery
Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …
Glycan changes: cancer metastasis and anti-cancer vaccines
M Li, L Song, X Qin - Journal of biosciences, 2010 - Springer
Complex carbohydrates, which are major components of the cell membrane, perform
important functions in cell-cell and cell-extracellular matrix interactions, as well as in signal …
important functions in cell-cell and cell-extracellular matrix interactions, as well as in signal …