Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …

Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-
known markers of tumor progression. This chapter discusses glycan biosynthetic pathways …

Glycosylation is catalyzed by various glycosyltransferase enzymes which are mostly located
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …

Abstract Changes in glycosylation are often a hallmark of disease states. For example,
cancer cells frequently display glycans at different levels or with fundamentally different …

Cancer is a deadly disease that encompasses numerous cellular modifications. Among
them, alterations in glycosylation are a proven reliable hallmark of cancer, with most …

Complex carbohydrates, which are major components of the cell membrane, perform
important functions in cell-cell and cell-extracellular matrix interactions, as well as in signal …