Abstract Knowledge about the clinical significance of V-Raf Murine Sarcoma Viral Oncogene
Homolog B1 (BRAF) mutations in colorectal cancer (CRC) is growing. BRAF encodes a …

Simple Summary Colorectal cancer with a mutation in an oncogene BRAF has paid much
attention, as it comprises a population with dismal prognosis since two decades ago. A …

Simple Summary In colorectal cancer, mutations of the KRAS and BRAF genes are quite
common and can contribute to the activation of cell signaling pathways that lead to cell …

Experts have long appreciated that the clinical entity we call colorectal cancer is a
phenotype made up of numerous different genotypes, accounting for the wide variation in …

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAP-kinase signaling
pathway. While previously considered mutually exclusive, concomitant mutations in both …

BRAF mutations, present in 5 to 10% of colorectal cancers, have a proved oncogenic effect
which is linked to their implication in the RAS/MAPK intracellular signalling pathway and …

In recent years, studies on the molecular typing of colorectal cancer have matured, and the V-
raf murine sarcoma viral oncogene homolog B (BRAF) of the mitogen-activated protein …

Colorectal cancer is the second most common cause of cancer death in the United States.
Understanding the biochemical pathways underlying carcinogenesis has paved the way for …

Colorectal cancer (CRC) is still one of the deadliest cancer-related diseases. About 10% of
CRC patients are characterized by a mutation in the B-Raf proto-oncogene serine/threonine …

Purpose Our purpose was development and assessment of a BRAF-mutant gene
expression signature for colon cancer (CC) and the study of its prognostic implications …