Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …

Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2

M Gheblawi, K Wang, A Viveiros, Q Nguyen… - Circulation …, 2020 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

COVID-19, ACE2, and the cardiovascular consequences

AM South, DI Diz, MC Chappell - American Journal of …, 2020 - journals.physiology.org
The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to
patients with underlying cardiovascular disease (CVD). The mechanism for SARS-CoV-2 …

ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: potential therapeutic targeting

S Sharifkashani, MA Bafrani, AS Khaboushan… - European journal of …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that
uses the human angiotensin-converting enzyme 2 (ACE2) receptor as a point of entry. The …

[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator

J Bian, Z Li - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 …

[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy

PK Datta, F Liu, T Fischer, J Rappaport, X Qin - Theranostics, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

[HTML][HTML] SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

S Gross, C Jahn, S Cushman, C Baer… - Journal of molecular and …, 2020 - Elsevier
The current COVID-19 pandemic started several months ago and is still exponentially
growing in most parts of the world–this is the most recent and alarming update. COVID-19 …