A series of C9-substituted phenanthrene-based tylophorine derivatives (PBTs) were
designed, synthesized, and first evaluated for their antiviral activities against tobacco mosaic …

Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine,
and optically pure alkaloids S-(+)-tylophorine and R-(−)-tylophorine were synthesized and …

On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of phenanthrene-based antofine derivatives (1–12 and 18–50) were …

On the basis of our previous studies on the antiviral mechanism against tobacco mosaic
virus (TMV) and structure–activity relationship of phenanthroindolizidine alkaloids, a series …

BACKGROUND The phenanthroindolizidine alkaloid antofine and its analogues have
excellent antiviral activity against tobacco mosaic virus (TMV). To simplify the structure and …

To study the influence of the substituent at the N-10 position on antiviral activity, the chiral
quaternary ammonium salt derivatives of R-and S-tylophorine were designed, synthesized …

A series of phenanthroquinolizidine alkaloids 1–24 were prepared and first evaluated for
their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that …

On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of phenanthroindolizidines and their analogues 3–20 were designed …

Plant diseases seriously affect the yield and quality of crops and are difficult to control.
Tryptanthrin and its derivatives (tryptanthrins) were synthesized and evaluated for their …

To investigate the influence of the variation of the original skeletons of natural
phenanthroindo/quinolizidine alkaloids on antiviral activities, two types of structurally totally …