To explore the variability in biosensor studies, 150 participants from 20 countries were given
the same protein samples and asked to determine kinetic rate constants for the interaction …

The introduction of affinity-based biosensors has permitted label-free functional analysis of
biomolecular interactions in real time. A variety of methods are now based on BIACORE® …

The classical method of measuring binding constants with affinity-based biosensors involves
testing several analyte concentrations over the same ligand surface and regenerating the …

Despite the amount of resources that have been invested by national and international
academic, government, and commercial sectors to develop affinity-based biosensor …

Today, affinity-based biosensorics is a standard technology in quantitative biomolecular
interaction analysis, but suffers from low sample throughput and sometimes from …

Molecular biorecognition processes facilitate physical and biochemical interactions between
molecules in all crucial metabolic pathways. Perhaps the target analyte and the …

Proteins are used as biocatalysts, therapeutic or diagnostic agents, and as such they are
biotechnological products. Moreover, they are biomarkers for health states, diseases or toxic …

Whereas the concentration of a biomolecule simply refers to the amount of chemical
substance per unit of volume, its active concentration refers to a relational parameter that …

The past few years have seen a dramatic change in biosensor technology. This change can
be attributed to the convergence of three different strands of research: a. Researchers have …

Using both experimental assays and fluid-dynamic finite element simulation models, we
directly compared the achievable performance limits of four distinct assay configurations for …