Investigating biophysical cellular interactions in the circulation currently requires choosing
between in vivo models, which are difficult to interpret due in part to the hemodynamic and …

Cell signalling and mechanics influence vascular pathophysiology and there is an
increasing demand for in vitro model systems that enable examination of signalling between …

Irregular hemodynamics affects the progression of various vascular diseases, such
atherosclerosis or aneurysms. Despite the extensive hemodynamics studies on animal …

Endothelial barrier function is known to be regulated by a number of molecular mechanisms;
however, the role of biomechanical signals associated with blood flow is comparatively less …

The vascular endothelium forms the inner lining of blood vessels and actively regulates
vascular permeability in response to chemical and physical stimuli. Understanding the …

Abstract Organ-on-a-chip (OOC) platforms involve the miniaturization of cell culture systems
and enable a variety of novel experimental approaches. These range from modeling the …

Blood vessel models are increasingly recognized to have value in understanding disease
and drug discovery. However, continued improvements are required to more accurately …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …

As we move toward developing ever more complex in vitro systems, the ability to incorporate
functional vasculature constitutes a critical step toward building physiologically relevant …