Background The exposure of the peritoneum to desiccation during surgery generates lasting
damage to the mesothelial lining which impacts inflammation and tissue repair. We have …

Introduction Avoiding tissue desiccation is a common recommendation to reduce
postoperative complications following open abdominal surgery, although difficult to achieve …

Background CO 2 pneumoperitoneum (PP) during laparoscopic surgery, can cause hypoxia
and desiccation in the peritoneal mesothelial cell, resulting in a time-dependent retraction …

BACKGROUND: Pneumoperitoneum may be responsible for ultra-structural alterations in
the mesothelium during laparoscopy. To characterize the effect of pneumoperitoneum on the …

Background The aim of this study was to monitor the effect of humidified-warm carbon
dioxide (HWCO2) delivered into the open abdomen of mice, simulating laparotomy. Methods …

Purpose The addition of 4% O 2 and 10% N 2 O to the CO 2 pneumoperitoneum (PP),
together with slight cooling and humidification (conditioning), contributes to reducing …

Background Animal experiments have suggested that the laparoscopic peritoneal
environment is hypoxic. This study aimed to investigate whether peritoneal tissue is hypoxic …

Peritoneal fluid dwell impacts the peritoneum by creating an abnormal physiological
microenvironment. Little is known about the precise effects of fluid dwell on the peritoneum …

BACKGROUND Previous animal studies suggested that the peritoneal environment during a
carbon dioxide (CO2) pneumoperitoneum is hypoxic and that this may contribute to the …

Background The CO 2 pneumoperitoneum, which is used for laparoscopic surgery, causes
local and systemic effects in patients. Concern arises about what the pressurized anoxic …