Background Crosstalk between tumor cells and their microenvironment plays a crucial role
in the progression of hepatocellular carcinoma (HCC). Hypoxia, a common feature of …

Hepatocellular carcinoma (HCC) is the most common form of liver cancer throughout the
world. The microenvironment of the HCC is composed of non-tumor cells and their stroma …

Angiogenesis has an important function in the proliferation and metastasis of hepatocellular
carcinoma (HCC) under a hypoxic tumor microenvironment. Activated hepatic stellate cells …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

Hepatocellular carcinoma (HCC) is one of the most rapidly growing and prevalent cancers in
the whole world. The characterized hypoxia region inside the HCC tumors has been recently …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

Purpose: Aberrant activation of β-catenin contributes to the malignant phenotype in
hepatocellular carcinoma (HCC). Hypoxia is also known to promote HCC invasion and …

A growing body of literature highlights the cross-talk between tumor cells and the
surrounding peri-tumoral stroma as a key modulator of the processes of …

Background & Aims Expression of liver progenitor cell (LPC) characteristics has been
proposed as a negative prognostic marker in primary liver tumors. Hypoxia has been linked …

Background Tumor microenvironment (TME) plays a very important role in cancer
progression. The mesenchymal stem cells (MSC), a major compartment of TME, have been …