At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …

Simple Summary Several pieces of evidence indicate an impact of oxidative stress (OS) in
the pathogenesis and progression of thyroid cancer. The aim of the study was to investigate …

Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are
becoming a serious social problem with rapidly increasing prevalence. The latter is …

Reactive oxygen species (ROS) are the most critical class of free radicals or reactive
metabolites produced by all living organisms. ROS regulate several cellular functions …

Oxidative stress (OS) is a state of excessive free radicals and reactive metabolites among
which the most important class is reactive oxygen species (ROS)–radicals derived from …

Simple Summary Increased oxidative stress (OS) has been implicated as a relevant risk
factor for cancer development and progression. The incidence of differentiated thyroid …

Somatic mutations can be identified in two-thirds of papillary and follicular thyroid
carcinomas and'hot'thyroid nodules, whereas equivalent mutations relevant for …

The most serious hallmark step of carcinogenesis is oxidative stress, which induces cell
DNA damage. Although in normal conditions ROS are important second messengers, in …

Reactive oxygen species (ROS), consisting mainly of superoxide, hydrogen peroxide and
hydroxyl radical, have been implicated in many diseases including cancer. ROS have been …

Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several
cell generations after the initial exposure. The thyroid gland is one of the most sensitive …