Trehalose and bacterial virulence

M Vanaporn, RW Titball - Virulence, 2020 - Taylor & Francis
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …

[HTML][HTML] Relevance of trehalose in pathogenicity: some general rules, yet many exceptions

H Tournu, A Fiori, P Van Dijck - PLoS Pathogens, 2013 - journals.plos.org
Trehalose, a natural disaccharide, consists of two glucose molecules linked by an a, a-1, 1-
glucoside bond. Apart from its function as a reserve carbohydrate, trehalose is known for its …

New insights on trehalose: a multifunctional molecule

AD Elbein, YT Pan, I Pastuszak, D Carroll - Glycobiology, 2003 - academic.oup.com
Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an α, α-
1, 1-glycosidic linkage. This sugar is present in a wide variety of organisms, including …

Physiological roles of trehalose in bacteria and yeasts: a comparative analysis

JC Argüelles - Archives of microbiology, 2000 - Springer
The disaccharide trehalose is widely distributed in nature and can be found in many
organisms, including bacteria, fungi, plants, invertebrates and mammals. Due to its particular …

[HTML][HTML] Trehalose Biosynthesis Promotes Pseudomonas aeruginosa Pathogenicity in Plants

S Djonović, JM Urbach, E Drenkard, J Bush… - PLoS …, 2013 - journals.plos.org
Pseudomonas aeruginosa strain PA14 is a multi-host pathogen that infects plants,
nematodes, insects, and vertebrates. Many PA14 factors are required for virulence in more …

[HTML][HTML] Trehalose is required for growth of Mycobacterium smegmatis

PJ Woodruff, BL Carlson, B Siridechadilok… - Journal of Biological …, 2004 - ASBMB
Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within
various immunologically relevant glycolipids such as cord factor and sulfolipid-1. By …

Trends in bacterial trehalose metabolism and significant nodes of metabolic pathway in the direction of trehalose accumulation

R Ruhal, R Kataria, B Choudhury - Microbial Biotechnology, 2013 - Wiley Online Library
The current knowledge of trehalose biosynthesis under stress conditions is incomplete and
needs further research. Since trehalose finds industrial and pharmaceutical applications …

[HTML][HTML] Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa

SD Woodcock, K Syson, RH Little, D Ward… - PLoS …, 2021 - journals.plos.org
An important prelude to bacterial infection is the ability of a pathogen to survive
independently of the host and to withstand environmental stress. The compatible solute …

Three pathways for trehalose biosynthesis in mycobacteria

KAL De Smet, A Weston, IN Brown… - …, 2000 - microbiologyresearch.org
Trehalose is present as a free disaccharide in the cytoplasm of mycobacteria and as a
component of cell-wall glycolipids implicated in tissue damage associated with …

Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance

AL Carvalho, FS Cardoso, A Bohn… - Applied and …, 2011 - Am Soc Microbiol
Trehalose accumulation is a common cell defense strategy against a variety of stressful
conditions. In particular, our team detected high levels of trehalose in Propionibacterium …