Naphthoquinone (2-NQ) is a nucleophile acceptor that non-selectively makes covalent
bonds with cysteine residues in various cellular proteins, and is also found in diesel exhaust …

The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable
aminoacids with 1, 4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB …

A series of novel indole based sulfonohydrazide derivatives (5a–k) containing morpholine
heterocyclic ring were synthesized through multistep chemical reactions. The target …

Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …

Background Multidrug resistance (MDR) has been regarded as one of the major hurdles for
the successful outcome of cancer chemotherapy. The collateral sensitivity (CS) effect is one …

Natural product derivatives are essential in searching for compounds with important
chemical, biological, and medical applications. Naphthoquinones are secondary …

A new series of ortho-naphthoquinone analogs of β-lapachone were designed, synthesized
and evaluated. The biological results indicated that most of our compounds were efficient …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …

Multidrug resistance (MDR) limits the therapeutic effect of conventional chemotherapeutic
agents as well as novel targeted anticancer drugs. An important mechanism of MDR is the …

Background: Cancer treatment often fails due to multidrug resistance (MDR) of the tumor
cells. One of the major causes is overexpression of P-glycoprotein (P-gp). Materials and …