Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP
H Pelletier, MR Sawaya, A Kumar, SH Wilson, J Kraut - Science, 1994 - science.org
Two ternary complexes of rat DNA polymerase β (pol β), a DNA template-primer, and
dideoxycytidine triphosphate (ddCTP) have been determined at 2.9 Å and 3.6 Å resolution …
dideoxycytidine triphosphate (ddCTP) have been determined at 2.9 Å and 3.6 Å resolution …
Crystal structure of rat DNA polymerase β: evidence for a common polymerase mechanism
MR Sawaya, H Pelletier, A Kumar, SH Wilson, J Kraut - Science, 1994 - science.org
Structures of the 31-kilodalton catalytic domain of rat DNA polymerase β (pol β) and the
whole 39-kilodalton enzyme were determined at 2.3 and 3.6 angstrom resolution …
whole 39-kilodalton enzyme were determined at 2.3 and 3.6 angstrom resolution …
A unified polymerase mechanism for nonhomologous DNA and RNA polymerases
TA Steitz, SJ Smerdon, J Jäger, CM Joyce - Science, 1994 - science.org
Extrapolating from the co-crystal structure of rat DNA polymerase 1 (pol 1) com-plexed with
primer-template, dideoxycytidine triphosphate (ddCTP), and two metal ions, H. Pelletier et …
primer-template, dideoxycytidine triphosphate (ddCTP), and two metal ions, H. Pelletier et …
Active Center of DNA Polymerase: The operations are localized and arranged in multiple sites within a single area of the molecule.
A Kornberg - Science, 1969 - science.org
DNA polymerases have now been isolated from a variety of bacterial and animal cells.
These enzymes, including those produced specifically in response to virus infection …
These enzymes, including those produced specifically in response to virus infection …
DNA-and RNA-dependent DNA polymerases
TA Steitz - Current Opinion in Structural Biology, 1993 - Elsevier
A catalytic subdomain of HIV reverse transcriptase has the same structure as that of E. coli
Klenow fragment, including three conserved carboxylates whose mutation destroys activity …
Klenow fragment, including three conserved carboxylates whose mutation destroys activity …
Crystal Structures of Human DNA Polymerase β Complexed with DNA: Implications for Catalytic Mechanism, Processivity, and Fidelity,
H Pelletier, MR Sawaya, W Wolfle, SH Wilson… - Biochemistry, 1996 - ACS Publications
Mammalian DNA polymerase β (pol β) is a small (39 kDa) DNA gap-filling enzyme that
comprises an amino-terminal 8-kDa domain and a carboxy-terminal 31-kDa domain. In the …
comprises an amino-terminal 8-kDa domain and a carboxy-terminal 31-kDa domain. In the …
Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates
E Arnold, J Ding, SH Hughes, Z Hostomsky - Current opinion in structural …, 1995 - Elsevier
DNA and RNA polymerases are enzymes that are primarily responsible for copying genetic
material in all living systems. The four polymerases whose structures have been determined …
material in all living systems. The four polymerases whose structures have been determined …
[HTML][HTML] DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase β: implication for the identity of the rate-limiting conformational …
BJV Berg, WA Beard, SH Wilson - Journal of Biological Chemistry, 2001 - ASBMB
Structures of DNA polymerase (pol) β bound to single-nucleotide gapped DNA had revealed
that the lyase and pol domains form a" doughnut-shaped" structure altering the dNTP …
that the lyase and pol domains form a" doughnut-shaped" structure altering the dNTP …
Genetic and crystallographic studies of the 3′, 5′-exonucleolytic site of DNA polymerase I
Site-directed mutagenesis of the large fragment of DNA polymerase I (Klenow fragment)
yielded two mutant proteins lacking 3′, 5′-exonuclease activity but having normal …
yielded two mutant proteins lacking 3′, 5′-exonuclease activity but having normal …
Structure of DNA polymerase I Klenow fragment bound to duplex DNA
LS Beese, V Derbyshire, TA Steitz - Science, 1993 - science.org
Klenow fragment of Escherichia coli DNA polymerase I, which was cocrystallized with
duplex DNA, positioned 11 base pairs of DNA in a groove that lies at right angles to the cleft …
duplex DNA, positioned 11 base pairs of DNA in a groove that lies at right angles to the cleft …