Kampo medicine is a form of Japanese phytotherapy originating from traditional Chinese
medicine (TCM). During the last several decades, much attention has been paid to the …

On the basis of the structures of ondansetron and GR 65,630, its ring-opened C-linked
methylimidazole analogue, novel 1, 7-annelated indole derivatives were synthesized as …

Alniditan, a novel migraine abortive agent, is a potent 5‐HT1B/5‐HT1D receptor agonist of
nm affinity. We compared the agonistic properties of alniditan, sumatriptan and …

The purpose of this study was to investigate the possible antinociceptive effect of
Heterotheca inuloides in inflammatory pain and to identify the main compounds involved in …

Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266
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Here we report the synthesis of N-(1, 2, 3, 4-tetrahydronaphthalen-1-yl)-4-aryl-1-
piperazinealkylamides 16− 29 that were designed to elucidate both structure− affinity and …

A series of C1, C2, C3 and N6 analogs of nantenine (2) was synthesized and evaluated in 5-
HT2A and α1A receptor functional assays. Alkyl substitution of the C1 and N6 methyl groups …

WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl) piperazinyl) ethyl))-N-(2-pyridinyl)
cyclohexanecarboxamide] 1 and its O-desmethyl derivative DWAY 2 are well-known high …